Anti-tubular action ,pharmacokinetics,adverse effects of Rifampicin
RIFAMPICIN : Its a semi-synthetic derivative of Rifamycin 1st line drug used in tuberculosis Rifampicin is bactericidal to M.tuberculosis,M.leprae Inhibits most gram positive and gram negative bacteria like staphylococcus aureus,N.meningitidis,E.coli,klebsiella,pseudomonas,proteus and legionella ANTI-TUBULAR ACTION: Tuberculocidal :treatment for tuberculosis Acts on intra and extracellular organism and drug resistant organism hence called - STERILISING AGENT Inhibit DNA dependent RNA synthesis if used alone it develops drug resistance Rifampicin Bind with beta subunit of DNA dependent RNA polymerase Inhibition of MRNA synthesis Tuberculocidal effect PHARMACOKINETICS: 1)ABSORPTION:Given orally 2)DISTRIBUTION:Penetrate cavities,caseous masses,placenta and meninges 3)METABOLISM :Liver 4)EXCRETION:Bile and urine T 1/2 : 2 hours INTERACT