Leptospirosis -cause,pathogenesis,clinical features,diagnosis and treatment
LEPTOSPIROSIS Leptospirosis is a zoonotic infection which is caused by spirochete ZOONOTIC DISEASE ? Zoonotic disease are infection that spread between animals and human Examples :plague,ebola,rabies SPIROCHETE? Spiral shaped bacteria Helically coiled Highly motile Disease caused by spirochaetes: lyme disease,syphilis,borreliosis LEPTOSPIROSIS Hook in ends Periplastic flagella Leptospirosis -animal reservoir is rat (rodent ) Spread through rat urine contaminated in flood water More common in rainy season LEPTOSPIRA SPECIES : PATHOGENIC -LEPTOSPIRA INTERROGANS FREE LIVING-LEPTOSPIRA BIFLEXA Leptospira dont stain well and are best seen in dark field microscopy with silver impregnation stain PATHOGENESIS : Leptospira common in rodent (rat) ,also known as rat fever When a person who has cut or abraded skin walks in flood , Sewage water mixed with rat urine ;leptospira enter in and cause infection Undergoes 2 phases: Phase 1- leptospiremia Phase 2-immune phase Biphasic illness