Showing posts from February, 2024

NECROSIS -pathology notes

  NECROSIS  DEFINITION: Its defined as the morphological changes taking place in a tissue after cell death due to degradative action f enzymes on irreversibly injured cell. TYPES OF NECROIS : A)CASEOUS NECROSIS B)LIQUEFACTIVE NECROSIS C)COAGULATIVE NECROSIS D)FIBRINIOD NECROSIS E)FAT NECROSIS F)GANGEROUS NECROSIS CYTOPLASMIC CHANGES : Increased eosinophilia of cytoplasm  Vacuolation and moth eaten appearance of cytoplasm  Calcification of cell membrane and intracellular structures  Formation of myelin figures  NUCLEAR CHANGES : KARYOLYSIS : Fading of basophilia of nucleus PYKNOSIS: Nuclear shrinkage due to condensation of chromatin  KARYORRHEXIS -Nuclear fragmentation  A)CASESOUS NECROSIS : Its seen in tuberculosis and occurs due to both enzymatic degradation of tissue and denaturation of cellular proteins  The tissue architecture is lost and replaced by soft ,creamy cheese like material  Microscopically ,there is amorphous granular debris seen  Examples : tuberculosis lymph node ,tube