PROTON PUMP INHIBITOR - MECHANISM OF ACTION ,USES

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 PROTON PUMP INHIBITOR 

  • Peptic ulcer occurs due to the imbalance between acid -pepsin secretion and mucosal defense factor 
  • Proton pump inhibitor act by inhibiting the gastric acid secretion 
  • Its a efficacious inhibitor
  • omeprazole is a drug that's commonly use









MECHANISM OF ACTION:

  • The parietal cells of stomach secrete :H + with the help of enzyme H+K+ATPase present in the plasma membrane

  • Omeprazole and other proton pump inhibitor are produrg get activated in the acidic environment of the stomach to sulfenamide which binds covalently with H+K+ATPase
 
  • The binding is irreversible

  • Single dose can almost (95%)inhibit gastric secretion

Acid secretion start only after new H+K+ATPase enzyme is synthesises .
  • Ulcer heals rapidly even in resistant cases.




PHARMACOKINETICS;
  • Given as enteric coated granules to avoid degradation by acid in stomach
  • Effect of 1 dose remains for 2 to 3 days
  • Microsomal enzyme inhibitor
  • Increases level of benzodiazepine,warfarin 
ADVERSE EFFECT :
  • Headache
  • Nausea
  • Pain
  • Long term adverse effect :
  • vitamin B12 deficiency
  • Increases gastrin level 

DRUG INTERACTION;
  • Decreases gastric acidity -H2 receptor ,antacid
  • lansoprazole similar to omeprazole is longer acting 
USES:
  • Ulcer heal fast ,pain is relieved
  • Component of  H.pylori treatment 
  • Useful in zollinger ellison syndrome.
AIM OF THIS POST:

vanakkam,the previous post was about peptic ulcer drug do check it  out then come back to this post to understand better .today we started with a small introduction of what a proton pump inhibitor is then we moved on into mechanism of action later the drug interaction of course as like all drugs proton pump inhibitor also have adverse effect ,hope this post would have been informative if it helped you all do let me know in the comment section below .

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