Papillary carcinoma thyroid -etiology, pathology, clinical features, treatment

-

 PAPILLARY CARCINOMA THYROID 

  • Thyroid gland is the only endocrine gland where in malignant tumor spread by all possible routes:

Local 

Lymphatic 

Blood

  • Thyroid gland is the only endocrine gland where in malignant tumors are usually non -functional








ETIOLOGY:

  • Accidental radiation to neck /Hodgkin lymphoma result in papillary carcinoma of thyroid
  • It can be complication of hashimoto thyroiditis
  • Occur often in gardner syndrome ,Cowden syndrome patient associated with mutation :chromosomal translocation involving RET PROTO ONCOGENE ,Chromosome (10q11)



PATHOLOGY:

  • Its made up of colloid like filled follicles 
  • calcific lesion are found which are called PSAMOMA BODIES
  • Follicular variant of papillary cancer : LINDSAY TUMOUR
  • Mixed lesion
  • Tall cell papillary cancer :Aggressive, rapidly growing tumor 

Calcification 

Cystic changes

Cuboidal pale cells

Crowded nuclei

Cytoplasmic inclusion -intranuclear

Cartoon character -ORPHANANNIE 

Calcified deposits: PSAMMOMA BODIES







CLINCIAL FEATURES:

  • Age:20-40 yrs
  • Females are affected than males
  • Present as solitary nodule 
  • Its less than 1.5cm in diameter
  • Slow growing 
  • It may be palpable even when thyroid gland is not palpable 




TREATMENT :

TREATMENT OF PRIMARY 

A)TOTAL THYROIDECTOMY 

B)LOBECTOMY 

Removal of one lobe and entire isthmus 

Tumor multicentricity has little prognostic significance


 

STUDENTS CORNER:

Vanakam ,hope you all are doing great here is a yet another important topic from all aspect ,there are many key terminology such as LINDSAY TUMOUR,ORPHAN ANNIE CELS,PSAMOMA BODIES must know concept do learn them well as there is lots of potential to be asked in any competitive exams.

Comments

Post a Comment

Popular posts from this blog

Sterilization technique in microbiology

-
Image
HELLO! DOCTOR VANAKAM, I hope you all are doing good today we will be discussing sterilization various methods of sterilization, about dry heat sterilization and moist heat sterilization along with different methods employed, and what are the materials to be placed in this method in detail about autoclave its principle, working and of course uses. As I have had already informed you all through my previous post on the contribution of Louis Pasteur and Koch postulates if we haven't checked it out yet do check it out using this link   https://www.stencildent.com/2020/07/contributions-of-louis-pasteur-and-koch.html  wherein I would explain the importance for the need of the HOUR and always to sterilize things to and from the patients and also get geared up for the next post on SHOCK wherein I would cover the definition, types, classification along with etiology, pathogenesis, flow chart, the complication of septic shock in detail so now without any further ado lets get starte...
Read more

STAGES AND STEPS IN TOOTH PREPARATION

-
Image
                      STAGES AND STEPS IN                                        TOOTH  PREPARATION                 TOOTH PREPARATION INVOLVES 2 STAGES  1) INITIAL TOOTH PREPARATION:    OUTLINE FORM AND INITIAL DEPTH PRIMARY RESISTANCE FORM  PRIMARY RETENTION FORM CONVENIENCE FORM 2) FINAL TOOTH PREPARATION  REMOVAL OF REMAINING CARIES PULP PROTECTION SECONDARY RESISTANCE AND RETENTION FORM FINISHING OF EXTERNAL WALL FINAL PROCEDURE OF CLEANING AND INSPECTING  Each stage and step is explained in detail please refer to above notes . note:please do not  download and share all rights are reserved to stencildent.
Read more

Hypersensitivity microbiology notes

-
Image
                          HYPERSENSITIVITY   hello, doctor vanakam, I hope you all are doing good, as intimated through the last post on anaerobic culture method  https://www.stencildent.com/2020/08/anaerobic-culture-methods-microbiology.html  if u haven't checked it out do read using this link without any further ado lets get started. CONTENTS: 1)Definition 2)Classification 3)type 1 hypersensitivity reaction a)1st exposure b)2nd exposure c)mediators of reaction d)late-phase reaction 4)type 4 hypersensitivity 5)treatment  1)DEFINITION: It refers to a condition in which immune response results in excessive reaction leading to tissue damage, disease, or even death in a sensitised host. 2) CLASSIFICATION: Coomb and gel classification in 1963 into type 1 to 4  Type 1,    type 2, type 3       : They depend on the interaction of antigen with humoral antibodies They are the i...
Read more