How Amoxicillin -Clavulanic Acid Overcomes Beta Lactamase Resistance

-

                             AMOXICILLIN 

  • Amoxicillin is a broad spectrum antibiotic beta lactam antibiotic, but its susceptible to degradation by beta lactamase enzymes produced by certain bacteria .
  • Its susceptible to degradation by beta lactamase producing bacteria.
  • They are resistant to broad spectrum beta lactam antibiotics 
  • Amoxicillin is combined with clavulanic acid which is beta lactamase inhibitor 
  • Clavulanic acid binds to beta lactamase -clavulanic acid get inactivated known as suicide inhibitor

MECHANISM OF ACTION :

Amoxillicin gets degraded easily by attack of bacteria thus resulting in its breakdown ,where as when amoxicillin gets combined with clavulanic acid ,it doesn't get degraded easily thereby aid in destroying the bacterial pathogens .




Comments

Post a Comment

Popular posts from this blog

Sterilization technique in microbiology

-
Image
HELLO! DOCTOR VANAKAM, I hope you all are doing good today we will be discussing sterilization various methods of sterilization, about dry heat sterilization and moist heat sterilization along with different methods employed, and what are the materials to be placed in this method in detail about autoclave its principle, working and of course uses. As I have had already informed you all through my previous post on the contribution of Louis Pasteur and Koch postulates if we haven't checked it out yet do check it out using this link   https://www.stencildent.com/2020/07/contributions-of-louis-pasteur-and-koch.html  wherein I would explain the importance for the need of the HOUR and always to sterilize things to and from the patients and also get geared up for the next post on SHOCK wherein I would cover the definition, types, classification along with etiology, pathogenesis, flow chart, the complication of septic shock in detail so now without any further ado lets get starte...
Read more

Hypersensitivity microbiology notes

-
Image
                          HYPERSENSITIVITY   hello, doctor vanakam, I hope you all are doing good, as intimated through the last post on anaerobic culture method  https://www.stencildent.com/2020/08/anaerobic-culture-methods-microbiology.html  if u haven't checked it out do read using this link without any further ado lets get started. CONTENTS: 1)Definition 2)Classification 3)type 1 hypersensitivity reaction a)1st exposure b)2nd exposure c)mediators of reaction d)late-phase reaction 4)type 4 hypersensitivity 5)treatment  1)DEFINITION: It refers to a condition in which immune response results in excessive reaction leading to tissue damage, disease, or even death in a sensitised host. 2) CLASSIFICATION: Coomb and gel classification in 1963 into type 1 to 4  Type 1,    type 2, type 3       : They depend on the interaction of antigen with humoral antibodies They are the i...
Read more

STAGES AND STEPS IN TOOTH PREPARATION

-
Image
                      STAGES AND STEPS IN                                        TOOTH  PREPARATION                 TOOTH PREPARATION INVOLVES 2 STAGES  1) INITIAL TOOTH PREPARATION:    OUTLINE FORM AND INITIAL DEPTH PRIMARY RESISTANCE FORM  PRIMARY RETENTION FORM CONVENIENCE FORM 2) FINAL TOOTH PREPARATION  REMOVAL OF REMAINING CARIES PULP PROTECTION SECONDARY RESISTANCE AND RETENTION FORM FINISHING OF EXTERNAL WALL FINAL PROCEDURE OF CLEANING AND INSPECTING  Each stage and step is explained in detail please refer to above notes . note:please do not  download and share all rights are reserved to stencildent.
Read more