HOW TO FIND ORAL SUBMUCOSAL FIBROSIS IN A PATIENT?
ORAL SUBMUCOUS FIBROSIS DEFINITION SIRSAT AND PINDBORGS : An insidious chronic disease affecting any part of oral cavity and sometimes pharynx,occasionally preceded by /associated with vesicle formation and always associated with juxta epithelial inflammatory reaction followed by hyalinisation of lamina propria with epithelial atrophy leading to stiffness of oral mucosa and progressive limitation in mouth opening In 1952,SG JOSHI coined the term oral submucous fibrosis ETIOLOGY: Arecanut Chilli Genetic Autoimmunity Composition of arecanut :alkaloid,flavonoid predisposing factors :Nutritional deficiency RATE OF INCIDENCE: 1984 - 4.5% 1990 - 7.6% 2000 - 13.33% PATHOGENESIS: Oral mucosa Betel quid habit Constant irritation Chronic inflammation Activated t-cell and macrophage at the site Transforming growth factor : Increases collagen production,Decreases collagen degradation Increased collagen production FIBROSIS Increase in cytokines (interleukin-6,interferon gamma,tumour nec